com), IUPAC InChI (.inchi), IUPAC JCAMP-DX (.jdx. Read and write many popular chemical file types for working with the applications you use:ĪCD/ChemSketch Documents (.sk2), ChemDoodle Documents (.icl), ChemDoodle 3D Scenes (.ic3), ChemDoodle Javascript Data (.cwc.js), CambridgeSoft ChemDraw Exchange (.cdx), CambridgeSoft ChemDraw XML (.cdxml), Crystallographic Information Format (.cif), CHARMM CARD File (.crd), ChemAxon Marvin Document (.mrv), Chemical Markup Language (.cml), Daylight SMILES (.smi. Algorithmic Analysis of Cahn−Ingold−Prelog Rules of Stereochemistry: Proposals for Revised Rules and a Guide for Machine Implementation. and is 100% accurate in all 300 test cases provided. The CIP algorithm in ChemDoodle is validated against the test suite provided by Hanson et. Stereochemical features in your structures will be assigned "R", "S", "E", "Z", "M" and "P" descriptors. to remove any ambiguities and describe a completely consistent system for CIP assignments.ĬhemDoodle implements all 6 current CIP rules as well as auxilliary desciptors and mancude ring support. The most recent CIP rules from IUPAC were then algorithmically analyzed and standarized by Hanson et al. These rules were adopted by IUPAC for naming standards and fully described in the Blue books. While flawed, they have seen many revisions over the decades and were clarified by the work of Paulina Mata. The CIP rules have long been the standard for describing configurations of stereochemical features in a molecule.
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While Allison cries over being shot, Cole rushes up the stairs John pursues him, but is pushed over the banister, landing on a trophy that impales his neck.Ĭole escapes out his bedroom window and hides in the crawlspace under his house. Cole is forced to give the cult the police code to call off the other cops. When two cops arrive, Max kills one of them with a poker, but the other cop accidentally shoots Allison in the chest before Bee slits his throat. After they leave, he tries to escape out the window, but Bee secretly hides in his room and waits until Cole passes out from the exhaustion and loss of blood.īee and her cult question Cole, while fending off his questions by saying they needed his blood for a science project. He pretends to be asleep as Bee and the cult members enter his room to draw a sample of his blood. Cole hurries to his room where he calls 911, puts on his shoes, and finds his pocket knife. The others collect Samuel's blood, revealing themselves to be members of a demonic cult. However, as Bee kisses Samuel on a dare, she pulls two daggers from behind her back and stabs him in the skull. He sees Bee and several of her high school friends (Max, John, Allison, Sonya, and Samuel) playing a game of truth or dare formatted as a game of spin the bottle. Bee offers him some liquor to drink, but he secretly pours it out when she is not looking.Ĭole is encouraged by a text from his neighbor and other friend Melanie to go see what Bee gets up to after he goes to sleep. The following day, when his parents go out for an overnight stay at a hotel, Bee and Cole spend quality time together until he has to go to bed. Pre-teen student Cole Johnson is bullied by his neighbor Jeremy, but his babysitter Bee, who is one of his only two friends, stands up for him and scares Jeremy off. A sequel, The Babysitter: Killer Queen, was released on September 10, 2020. The film was released by Netflix on October 13, 2017, and received mostly positive reviews from critics. The film follows a lonely 12-year-old boy (Lewis) who discovers that his babysitter (Weaving) is part of a satanic cult that wants to kill him. It stars Samara Weaving, Judah Lewis, Hana Mae Lee, Robbie Amell and Bella Thorne. The Babysitter is a 2017 American teen black comedy slasher film directed by McG and written by Brian Duffield. Crusoe and Walker met in France in October 1951. Hershey's participation in the creation of the Thunderbird was more administrative than artistic. Boyer was the lead stylist on the original 1955 two-seater Thunderbird and also had input in the following series of Thunderbirds that included the 30th Anniversary Edition. The Thunderbird was similar in concept but was more American in style, more luxurious, and less sport-oriented.Ĭredit for the development of the original Thunderbird is given to Lewis Crusoe, a former GM executive lured out of retirement by Henry Ford II George Walker, chief stylist and a Ford vice president Frank Hershey, chief stylist for the Ford Division Bill Boyer, designer for the Body Development Studio, who became the manager of the Thunderbird Studio in the spring of 1955 and Bill Burnett, chief engineer. The completed one-off generated interest at the time, but had meager power, European looks, and a correspondingly high cost, so it never proceeded to production. Development Ī smaller two-seater sports roadster, named the Vega, was developed in 1953 at the behest of Henry Ford II. Thunderbird production ended in 1997, then briefly resumed as a two-passenger, marketed from 2002 to 2005.įrom its introduction in 1955 to its final phaseout in 2005, Ford produced over 4.4 million Thunderbirds. Sales were good until the 1990s when large two-door coupes became unpopular. Succeeding generations became larger until the line was downsized in 1977, again in 1980, and once again in 1983. For 1958, the Thunderbird was redesigned with a second row of seats. Ford positioned the Thunderbird as an upscale model and it is credited in developing a new market segment, the personal luxury car. Unlike the Chevrolet Corvette, it was not marketed as a sports car. The Thunderbird entered production for the 1955 model year as a sporty two-seat convertible. Introduced as a two-seat convertible, the Thunderbird was offered variously as a four-seat hardtop coupe, four-seat convertible, five-seat convertible and hardtop, four-door pillared hardtop sedan, six-passenger hardtop coupe, and five-passenger pillared coupe, with the final generation designed again as a two-seat convertible.įord targeted the two-seat Thunderbird as an upscale model, but the 1958 model year design introduced a rear seat and arguably marked the expansion of a market segment eventually known as personal luxury cars, positioned to emphasize comfort and convenience over handling and high-speed performance. The Ford Thunderbird (colloquially called the T-Bird) is a personal luxury car manufactured and marketed by Ford from model years 1955 to 2005 (with a 1997–2002 hiatus), across 11 generations. Sports car (first and eleventh generations).Benefiting handsomely from a high-quality restoration, this collector-grade 1963 ford Thunderbird Hardtop comes with a spare wheel/tire, roadside jack, First Aid kit, owners manual, and original ID tag. Factory features and amenities are numerous, including the standard automatic transmission, an AM radio, power brakes, steering, and window lifts, plus Fords innovative Tilt-A-Way steering column. Powered by a Z-Code 390 CI V-8 engine with 4-barrel carburetor, delivering 300 factory-rated horsepower, this 1963 Ford Thunderbird Convertible is exceptionally attractive and remains true to its factory specifications in Steel Blue over blue leather upholstery. Accordingly, the final-year Bullet Thunderbirds are particularly sought-after by todays most knowledgeable and passionate classic Thunderbird collectors. Underneath that handsome exterior, the 1963 Thunderbird also included additional sound deadening material and a quieter, longer-life exhaust system, plus myriad upgrades to the electrical system and accessories for improved reliability. Select revisions for 1963 included a new vertical-bar grille design and updates to the body sides and taillights. Four models were available for 1961-63, comprising the Hardtop, formal Landau Hardtop, Convertible, and for 1962-63, the Sports Roadster. Boasting unforgettable, projectile-like styling, this generation remains immensely popular with todays Thunderbird enthusiasts. Produced only for model years 1961 through 1963, the third-generation Bullet Bird Thunderbird design was relentlessly improved and updated throughout its brief production run. RECENTLY SERVICED, DETAILED, READY TO ENJOY! TILT-A-WAY STEERING COLUMN & POWER FRONT SEATS RARE OPTIONAL A/C & FABULOUS COCKPIT-STYLE INTERIOR JET ERA THUNDERBIRD IN SPECTACULAR CONDITIONīEAUTIFUL STEEL BLUE OVER BLUE COMBINATIONīUCKET SEATS POWER BRAKES, STEERING, WINDOWS You can edit or add the address if you have access to a Page's Facebook profile page. If you have task access to a Page, you can't modify its address. If you're having problems adding an address to your Page, you might want to change the category. There are still lots of questions regarding how to see someone's location on Facebook, so we've answered two of the most common questions regarding the said topic: Q1: Why can't I add location on Facebook page? All you need to do is install the application, and that's it! Easy, isn't it? FAQs: More About How to See Someone's Location on Facebook To make it even better, you can get all these perks without having to root the device. So, you will get information when the person uses social media such as Twitter, Snapchat, and many more. The application also gives information regarding the applications the device owner used. Of course, FamiGuard does more than track. Once the software is installed on the device, you can keep track of the device's location without having the need for their knowing about it. FamiGuard for Anrdoid is an application that allows you to track the device that has the application. If you want to know how to see someone's location on Facebook without their knowledge and you happen to use Android, you can use FamiGuard Pro for Android. Once the user click the link, you will get their IP address and location. The downside of this method is that it is a common method used by new hackers, and the person must click the link for us to know their IP address and location. IPLogger will create a link that, when clicked, will give the clicker's location and IP to the person who made the link. If the methods above still can't give you the person's location, you can track their IP address by using IPLogger. Open Check In and see the user's location history As long as the person checked in on Facebook and made the information open, you'll be able to see their check-in history. If you want to know how to see someone's location on Facebook in the past, you can use the Check In option. You can see someone's past check-ins to see where they have been. If your friends are near you and turn on their Nearby Friends, you'll see their names there. No worries, because the application will ask you to turn it on if you haven't. However, to activate this feature, you will need to turn your location on first. The application automatically finds the friends that are near your location. The Nearby Friends option is a location option if you want to see the location without having to look at the map or search it on Facebook. Click on the location you wanted to put on your post. Write the name of the location until the location appears on the drop-down. If you want to add a location tag, click on "Location" at the bottom of the post before posting. Look at the location tag at the top (for the post) or at the bottom (for a picture). Steps to check tags and hashtags on Facebook posts: It gives information to others, and it does allow you to flex on the location! Believe it or not, some people share the location where they took pictures by adding the location while posting. If someone regularly post photos, you can see someone's location on Facebook by seeing their location tag on their photos. How to share live location on Facebook Messenger: Just make sure you have good internet connection to share the location accurately. This is the most convenient way if you have direct access to Facebook since you directly share your location through GPS.Īlthough it might not be the most accurate by 200 meter-ish, you can gives the most accurate location since the information is directly from your phone. The first method you can do if you want to know how to find someone's location on Facebook is through "sharing the live location" feature. Free Ways to Track Someone's Location on Facebook Method 1. Part 2: How to See Someone's Location on Facebook Without Them Knowing įAQs: More About How to See Someone's Location on Facebook Part1. Part 1: 5 Free Ways to Track Someone's Location on Facebook About $360 million of the $400 million cost has been raised. ET-94, NASAs last-existing built-for-flight space shuttle external tank, takes to the sky assisted by two cranes for placement in the construction site for the California Science Centers new. In addition to completing the building, about 100 other aircraft and spacecraft will be installed along with numerous interpretive exhibits, Rudolph said. The 116-foot-long (35.3-meter-long) rocket motors were trucked to Los Angeles from the Mojave Desert in October and installed the following month. In use, the boosters would be attached to the external tank to help the shuttle’s main engines lift off. It began in July with precise installation of the bottom segments of the side boosters, known as aft skirts, for the first time outside of a NASA facility. The process of assembling the shuttle system in vertical configuration was dubbed “Go for Stack,” an informal term for putting together rocket components for launch. A groundbreaking ceremony for the Air and Space Center was held in 2022 on the 11th anniversary of Endeavour’s final return from space. The shuttle was initially displayed horizontally in a temporary exhibit hall. The external tank arrived by barge and made a similar trip across the city. The shuttle was flown to Los Angeles International Airport in 2012 atop a NASA Boeing 747 and then created a spectacle as it was inched through tight city streets to Exposition Park. It’s part of a collaboration with Google and YouTube.Endeavour flew 25 missions between 19, when NASA’s shuttle program ended. Watch Miles O’Brien’s LIVE webcast for spaceflightnow from Kennedy Space Center here.Īnd you can submit your questions for our special LIVE interview with the Endeavour crew, which is expected to take place three days after launch. It was named in a national contest by elementary school students after the British HMS Endeavor, the sailing ship commanded by 18th century explorer James Cook. In its short nine-year career, Endeavour has flown missions to fix a communications satellite, repair the Hubble Space Telescope and transported to space the first African-American woman, and the first married couple. It will also deliver spare parts, including two communication antennas and a high-pressure gas tank.Įndeavour was born out of tragedy - authorized in 1987 to replace the Challenger shuttle after the 1986 disaster. AMS is a massive supercooled magnet designed to soak up cosmic rays, and to search for dark matter and antimatter. The president still traveled to Cape Canaveral, despite the cancelling of the launch, and met with Giffords and Kelly.ĭuring its 14-day mission, the crew will deliver to the International Space Station a $2 billion particle physics detector, know as the Alpha Magnetic Spectrometer, or AMS. Giffords and President Barack Obama were expected to attend the launch. Kelly’s wife, Congresswoman Gabrielle Giffords, survived an assassination attempt in Tucson in January. “Unfortunate for the (Endeavour) team and Mark Kelly and his crew, but today the orbiter is not ready to fly and as we always say in this business, we will not fly before we’re ready,” said launch director Mike Leinbach. The heaters on one of the ship’s power units failed about four hours before liftoff. Space shuttle Endeavour, NASA’s youngest orbiter, was scheduled blast off into space for the final time at 3:47 pm EST Friday, marking the next-to-last scheduled launch of the shuttle program, but liftoff was delayed due to technical issues.Īccording to the AP, Commander Mark Kelly and his crew were on their way to the launch pad, when NASA halted the countdown. At least a 48 hour turnaround less than a minute ago via Facebook Favorite Retweet Reply Miles O’Brien The six crew members, led by commander Mark Kelly, are in Houston awaiting developments. The problem has been traced to a switchbox in the shuttle’s engine compartment. ET: NASA engineers have determined that the space shuttle Endeavour will not launch on May 2, and NASA has not yet set a new launch date. The new box is slated to get installed on Tuesday, followed by a series of tests. The plan is to remove and replace the box, which is expected to take several days to complete. There is no official launch date set yet.Ī 48-pound box of switches in the engine compartment that controls power feeds throughout the shuttle has been identified as the likely source of what caused heaters on a fuel line in an auxiliary power unit to fail on Friday. ET: The launch of shuttle Endeavour was postponed to no earlier than May 8 due to a faulty heating system, NASA officials said Sunday. less than a minute ago via web Favorite Retweet Reply NASA NASA shuttle & station managers met Monday & determined that Tuesday May 10 is the earliest Endeavour could be launched on STS-134. There was no evidence of cytokine release syndrome based on minimal participant symptoms and responses observed with other cytokines.Ĭonclusion: SON-1010, a novel presentation for rIL-12, was safe and well-tolerated in healthy volunteers up to 300 ng/kg. PK analysis showed two-compartment elimination in SB102 with mean T ½ of 104 h, compared with one-compartment elimination in SB101, which correlated with prolonged but controlled and dose-related increases in interferon-gamma (IFNγ). As expected with rIL-12, initial decreases in neutrophils and lymphocytes returned to baseline by days 9-11. All TEAEs were transient and no other dose relationship was noted. Results: Participants receiving SON-1010 at 100 ng/kg or higher tolerated the injection but generally experienced more treatment-emergent adverse effects (TEAEs) than those receiving the lowest dose. A non-compartmental analysis of PK was performed and correlations with the PD results were explored, along with a comparison of the SON-1010 PK profile in SB101. Safety was reviewed after day 22, before enrolling the next cohort. SON-1010 at 50-300 ng/kg or placebo administered subcutaneously on day 1 was studied at a ratio of 6:2, starting with two sentinels participants were followed through day 29. Methods: SB102 (NCT05408572) focused on safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) endpoints. After initiating a dose-escalation trial in patients with cancer (SB101), a randomized, double-blind, placebo-controlled, single-ascending dose (SAD) phase 1 trial in healthy volunteers (SB102) was conducted. We developed a strategy to extend the rIL-12 T ½ that depends on binding albumin in vivo to target tumor tissue, using single-chain rIL-12 linked to a fully human albumin binding (F HAB) domain (SON-1010). Despite some signs of efficacy since then, most rIL-12 clinical trials have encountered hurdles such as short terminal elimination half-life (T ½), limited tumor microenvironment targeting, and substantial systemic toxicity. Unexpected toxicity in the first phase 2 study required careful attention to revised dosing strategies. 6Nucleus Network Pty Ltd, Melbourne, VIC, Australiaīackground: The benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models.5InClin, Inc, San Mateo, CA, United States.4Centre for Medicine Use and Safety, Monash University, Melbourne, VIC, Australia.3Sarcoma Oncology Center, Santa Monica, CA, United States.2Momentum Metrix, LLC, Dublin, CA, United States.1Sonnet BioTherapeutics, Inc, Princeton, NJ, United States.Cini 1 Susan Dexter 1 Manuel DaFonseca 1 Justus Bingham 2 Isabelle Kuan 2 Sant P. Get ready for tacos and ceviche with small batch tequila and mezcal pairings. The menu, distinct from Border Grill’s Mexican fare, will be inspired by the chefs’ recent travels to Tijuana. Socalo will be open seven days a week with plans to serve breakfast, lunch, dinner, and happy hour. The restaurant’s name is a nod to both “SoCal” and zócalo, the Spanish word meaning town square, as Socalo has ambitions of being a central gathering place for the neighborhood. Socalo, which will be located inside the Gateway Hotel on the corner of Santa Monica Boulevard and 20th Street, is anticipated to open in the spring of 2019. The two chefs closed their 4th Street Santa Monica location of Border Grill in 2016. Now additional details are emerging about the restaurant’s name and projected opening date from the Santa Monica Daily Press. Eater previously reported that Susan Feniger and Mary Sue Milliken will be opening a new restaurant in Santa Monica. 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Rebirth’s format is unusual-45 minutes per episode, a rarity in anime-but it allows each episode to spotlight one of the signature enemy kaiju from the classic films in greater depth and pack in enough city-smashing action that you’ll be left asking "Godzilla who?" Set in 1989 Tokyo, this CG anime series follows youngsters Boco, Joe, and Junichi-and their bully Brody, an American whose parents work on a military base-as the world is besieged by hordes of monsters, with the barely understood force of nature that is Gamera the only thing that can stop them. Oh, and he’s also, canonically, “friend to all children.” It’s this latter point that serves as the basis for Gamera Rebirth, the first new project for the turtle titan in 17 years. He’s a giant, fire-breathing turtle with an impenetrable shell, one who can fly and become a flame-spewing, razor-edged, aerial spinning top of doom. While the latter has earned the epithet “King of the Monsters” and movie franchises in both its native Japan and the US, Gamera is perhaps best known as the subject of loving ridicule on Mystery Science Theater 3000. Gamera has never enjoyed the same respect that fellow kaiju Godzilla has. A far cry from the gag-a-minute approach of its creator’s earlier work, Disenchantment can be a bit of a slow burn at times, but with its drier comedy and rejection of an episodic status quo, it’s one of the most interesting adult animated comedies to come out of the US in years. With the aid of her personal demon, Luci, and a besotted elf bestie named Elfo, Bean flips the kingdom on its head, unearths ancient secrets, and battles her greatest enemy: her mom. “Would rather stay a drunken troublemaker” reluctant. Over the course of five seasons, it charts the journey of Princess Bean, who yearns to be free from her royal obligations to Dreamland, taking her from drunken troublemaker to reluctant hero. Go in with that expectation and you’ll be disappointed-this is a far more structured and arc-based show. Coming from The Simpsons creator Matt Groening, it was presented in opposition to his later Futurama, lazily swapping sci-fi for fantasy. Netflix screwed up the pitch on Disenchantment. With eight episodes, each around an hour long, this is as prestigious as any live-action thriller the streamer has produced, and a testament to both Tezuka and Urasawa's respective geniuses. This adaptation is not only a faithful recreation of Urasawa's retelling, but is stunningly animated to a standard rarely seen in Netflix's original anime productions. Meanwhile, Atom (Astro's Japanese name) is recast as a former peace ambassador, effectively a propaganda tool rolled out at the end of the 39th Central Asian War, still dealing with trauma from the experience. The focus shifts from the heroic boy robot to grizzled cybernetic detective Gesicht as he investigates a series of murders of both humans and robots, each victim left with makeshift horns crammed into their heads. In 2003, Naoki Urasawa ( Monster, 20 th Century Boys) updated original creator Osamu Tezuka's hugely influential "The Greatest Robot on Earth" story arc for his manga Pluto, opting for a more adult approach. You never have enough time, money or resources to do everything that is needed. Share this: Why is Everything Free We know what it is like working in a church, we work there too. 7 Motion Background Loops Motion Backgrounds fall. Since launching, we’ve seen over 10 million downloads of these images. Fall Focus 7 Free Background Loops This Free Media Is Provided By. 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Please help me (Superpower Defence) Ive beat all the missions up until this one, which is reallyyyyyy trying my patience. It may take you a while until you figure out the right way to expand your island. shadowgate vr the mines of mythrok walkthrough. On a related note, increase the budget on all production buildings, why not? Tropico 6: Superpower Defence (mission 11) full playthrough + win with gameplay. You have a Juicery that can turn Bananas and Pineapples into Juice, considering making more of those, you can easily make more Bananas and Pineapples.ĭon't forget to first increase the budget of your Power Plants instead of building more, should you find yourself low on power. Leather can be processed at the Fashion Company into Apparel. Near the power plants I build a weapons factory, plastics factory, electronics factory and a car factory. Along the way you have 2 deposits of gold, build those. Build a road from there towards your town. I tried various attempts but the economy wont work out at all. There is already a Factory Ranch (Crocodiles) that turns fish into leather. Here's how I build a stable economy: On the top left you have that fishing wharf and teamster port. 11th mission 'Superpower Defence' on hard. Tropico 6 Guide is a collection of the best tips to help you build a functioning state. Get another steel mill up and running, as well as two weapons factories, accept the objective related to this and enjoy the Weapons export route (don't forget to select the largest size deal, you'll use this trade route forever). You start with several mines and a steel mill already. Tropico 6: Superpower Defence (mission 11) full playthrough + win with gameplay MLMariss 12. Win a Sandbox game on an island with Relentless Disasters. Industrialization edict is a must, 50% cheaper industry! Tropico 6: Festival has a new five map mini-campaign for you to enjoy as you combat the boredom. Speedway might also be a good idea, as you have pretty long roads on your island. Employee of the month is a no-brainer: longer shifts in factories and mines = bigger profits. There is already a Research Lab on the island, so research is not a problem. You start with everything you need to succeed, including buildings for Tropican satisfaction, so don't be afraid to greatly expand your industry! It can take a while for your economy to stabilize as your factories get built and supply lines get set in motion, so don't get discouraged if you see your treasury dip into huge negatives (I got to -$100k, now climbed back up to $10k, shortly after it became $70k and building more industry), that's just how things go. Level: Tropico’s Healing Hands (Going Viral DLC) Medium Difficulty. |
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